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首页> 外文OA文献 >Compliance With a Structured Weight Loss Program Is Associated With Reduced Systolic Blood Pressure in Obese Patients With Chronic Kidney Disease
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Compliance With a Structured Weight Loss Program Is Associated With Reduced Systolic Blood Pressure in Obese Patients With Chronic Kidney Disease

机译：肥胖的慢性肾脏病患者对结构性减肥计划的依从性与收缩压降低有关

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Background: The effectiveness of lifestyle-based weight loss programs in obese patients with chronic disease has not been widely studied. This study examined the effectiveness of a weight management program (WMP), and sought to determine factors associated with successful weight loss in obese patients with chronic kidney disease (CKD).Methods: In this prospective cohort study, all patients with a body mass index (BMI) of >30 kg/m2 referred to our clinic from January 2005 to December 2008 and who commenced a structured WMP of an energy-reduced renal diet, exercise, and pharmacotherapy were included in the analyses. Changes in body weight and associated variables up to 24 months were assessed with intention-to-treat mixed linear models and predictors of weight loss were identified with multiple linear regression.Results: One hundred and thirty-five patients (56% male), of mean age 52.2 years and BMI 36.4 kg/m2 commenced the WMP. Significant weight loss was achieved for all patients at 6, 12, 18, and 24 months. Weight loss at 12 months was predicted by compliance and age, but not by baseline BMI, blood pressure (BP), stage of CKD or pharmacotherapy use. Greater compliance was associated with decreased systolic BP, with no change in mean antihypertensive medication dose.Conclusions: Significant weight loss was achieved, demonstrating the effectiveness of the WMP, and compliance with a structured program improved weight loss and systolic BP.
机译：背景：基于生活方式的减肥计划在肥胖的慢性病患者中的有效性尚未得到广泛研究。这项研究检查了体重管理计划（WMP）的有效性，并试图确定与肥胖的慢性肾脏病（CKD）患者成功减肥相关的因素。方法：在这项前瞻性队列研究中，所有患者的体重指数（BMI）> 30 kg / m2，从2005年1月至2008年12月转诊给我们的诊所，该研究包括开始进行结构化WMP的节能肾脏饮食，运动和药物治疗。使用意向性治疗混合线性模型评估了体重变化及相关变量直至24个月，并通过多元线性回归确定了体重减轻的预测指标。结果：135例患者（男性56％）中，平均年龄52.2岁，体重指数36.4 kg / m2开始了WMP。在6、12、18和24个月时，所有患者的体重均明显减轻。通过依从性和年龄可预测12个月的体重减轻，但不能通过基线BMI，血压（BP），CKD阶段或药物治疗来预测体重减轻。较高的依从性与收缩压降低有关，平均降压药物剂量无变化。结论：体重减轻显着，证明了WMP的有效性，对结构化程序的依从性改善了体重减轻和收缩压。

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